| CAS | |
| EINECS | |
| 化学式 | C17H19ClN2S |
| 分子量 | 318.86 |
| InChI | InChI=1/C17H19N2S.ClH/c6(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1 |
| 密度 | 1.301g/cm3 at 20℃ |
| 熔点 | 211-212 °C (decomp) |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | 甲醇: 可溶物1mg/mL |
| 存储条件 | Store below +30°C. |
| 外观 | 粉末 |
| 颜色 | Yellow to ochre-yellow |
| BRN | 3922452 |
| MDL号 | MFCD00011944 |
| 体外研究 | Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission. |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| TSCA | Yes |
| 海关编号 | 32041300 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 2-(4-氨基)-6-甲基苯并噻唑 |
| 参考资料 查看更多 | 1. 王瑞 朱文清 郑洁 等. 原儿茶酸对人血清白蛋白淀粉样纤维化的抑制作用[J]. 分析科学学报 2020 v.36(02):14-18.2. 郝徐艺, 罗思, 程淑意,等. 当归芍药散对AD细胞模型铜离子介导的Aβ聚集的影响[J... |
硫黄素T，也被称为硫胺素T或维生素B1，是一种重要的维生素。
性质：
硫黄素T是一种水溶性白色结晶性粉末，具有微弱的味。它是稳定的，在光线、热和酸性条件下相对稳定。它在碱性环境下会迅速降解。
用途：
硫黄素T是一种必需的维生素，对维持人体正常的代谢功能至关重要。硫黄素T还被用于防治硫黄素T缺乏症，该病在饮食中缺乏硫胺素T时会引发。
制法：
硫黄素T可以通过化学合成的方法制备。最常用的方法是以1-甘醇-3-酮为起始原料，经过多步反应制得硫黄素T。硫黄素T也可以通过天然来源，如酵母和谷类中提取得到。
安全信息： 通常情况下，正常剂量的硫黄素T不会产生明显的副作用。过量摄入硫黄素T可能导致胃肠道不适或过敏反应。对于孕妇和有慢性疾病的人群，应在医师的指导下使用。